Anjali Joshi is an accomplished technology executive and electrical engineer who has held important leadership roles in several high-growth companies. Joshi is an eleven year veteran at Google, Inc. where she served as Vice President for Product Management. During her tenure at Google she led teams on marquee Google products such as Search and adapted cutting edge technologies to solve major healthcare issues in underserved populations. Ms. Joshi received her B.Tech. in Electrical Engineering from IIT Kanpur in 1981. Following it, she went to the USA and obtained her master’s degree in Computer Engineering from the State University of New York and another master’s in Engineering Management from Stanford University.
When: June 17, 1999
“Evolutionary Fits and Survival for Gene Therapy and Drug Design”
Gary Nolan, Ph.D.
(Assistant Professor Departments of Molecular Pharmacology, Microbiology and Immunology, Stanford School of Medicine, founder of Rigel Inc.)
1993-present Assistant Professor
(March 1993-present) Department of Molecular Pharmacology, Stanford University School of Medicine
1995-present Assistant Professor (September 1995-present), Joint Appointment Department of Microbiology and Immunology, Stanford University School of Medicine
Rel and Ankyrin proteins in the regulation of pathologic disease states: HIV and Leukemia. Multi-parameter single cell measures of gene regulation by flow cytometric analysis. Dominant negative analysis of NF-kB signal transduction cascades. High-Titre retroviral production systems
Honors and Awards (Partial list)
Leukemia Society Special Fellow: July 1992-June 1995.
Leukemia Society Scholar Award: July 1995-June 2000.
Hume Faculty Scholar: 1993-1998
Board of Trustees, Leukemia Society of America, Northern California: 1995-1998.
1996 Burroughs Wellcome Fund New Investigator Award: July 1996 – June 2000.
Stanford University: Howard Hughes Medical Institute Junior Faculty Scholar Award. May 1997 – April 1998
Our laboratory focuses on signal transduction and gene regulation using the NFAT/Rel and IkB/ankyrin families of transcriptional regulators. Rel/ankyrin polypeptide complexes regulate transcription of numerous genes important to immune system function and cell division, including IL-2, IL-6, IFN-b, c-myc and HIV. Importantly, HIV-I, the causative agent of AIDS, parasitizes Rel/ankyrin complexes for its transcriptional enhancer elements. Rel/ankyrin polypeptides form complexes in the cytoplasm and nucleus of cells. Upon appropriate cellular stimulation, the complexes can be induced to move from the cytoplasm to the nucleus, undergo tertiary structural changes while binding DNA, or assume transcriptionally-active DNA-bound forms. Under certain conditions, the Rel/ankyrin proteins have pathologic activities and can lead to the causation of leukemia and other cancers.
In our laboratory we utilize techniques for the study of protein-protein association, protein DNA dialectic interaction, and transcriptional regulation during differentiation of B- and T- immune system cells. We employ genetical and biochemical approaches, including novel technology for the analysis of transcription with complex populations of living cells using Fluorescence-Activated Cell Sorter (FACS) and retroviral library technologies for intracellular combinatorial chemistry. We have developed techniques for delivering libraries of cDNAs to cells using retroviral libraries for complementation cloning. Finally, the laboratory focuses on the use of retroviruses for gene therapy applications and has developed a variety of novel approaches for generating recombinant retroviruses.